How much glucosamine does a woman need
The cost of these and other non-vitamin supplements and herbal remedies is close to 21 billion dollars per year. They are touted not only as arthritis pain relievers but also as treatments to prevent joint disease. The case for these supplements protecting joint health or preventing arthritis is similarly weak. The study was stopped early for an unusual reason — those taking the supplement actually reported worse symptoms than those taking a placebo. This raises the possibility that taking glucosamine and chondroitin might make your joints feel worse than doing nothing. Does this spell the end of people taking glucosamine, chondroitin, or both?SEE VIDEO BY TOPIC: Glucosamine and Chondroitin 60 Capsules
SEE VIDEO BY TOPIC: What Are Glucosamine & Chondroitin? - Health SupplementsContent:
- Safe Use of Glucosamine and Chondroitin Sulfate Supplements
- Glucosamine and Chondroitin for Osteoarthritis Pain
- Glucosamine and Chondroitin for Osteoarthritis
- The latest on glucosamine/chondroitin supplements
- Glucosamine Sulfate
- What Is Glucosamine?
- Postmenopausal Women Benefit from Glucosamine
- Glucosamine: Should I try it?
- How Much Glucosamine Chondroitin Should You Take?
Safe Use of Glucosamine and Chondroitin Sulfate Supplements
As the only practitioner of complementary and alternative medicine in a multicenter practice in central Pennsylvania an area not known, at least in terms of its medical community, for embracing change , it can be frustrating to try to educate my colleagues on the usefulness of supplements in maintaining optimal health. Osteoarthritis OA is one of the most common and debilitating diseases to afflict middle-aged and elderly people. Despite decades of research on the origins and characteristics of OA, scientists are still not sure what causes this debilitating condition—and there is still no cure.
Remarkably, there is not even a drug that does anything more than relieve the pain of OA. Pain relief is a huge plus, of course, but it does nothing to improve the underlying condition.
Victims of OA have progressive degeneration of the joints. Up to the age of about 50, OA of the knees is more prevalent in men than in women; in the more elderly population, however, the incidence of knee OA increases more rapidly in women.
Both men and women with severe OA suffer not only from pain and stiffness caused by joint destruction, but also from significant loss of mobility, which can greatly interfere with every aspect of their lives.
Some NSAIDs, such as aspirin, acetaminophen, ibuprofen, and naproxen, are sold over-the-counter, but other, more powerful ones are prescription drugs that can be quite expensive. Although they can help ease the inflammation and pain of OA, they do nothing to retard the progression of this disabling disease. In addition, NSAIDs can have significant and potentially life-threatening side effects, such as gastrointestinal bleeding.
The answer, sadly, is very little. Physical therapy can be used to try to regain some of the mobility lost to the ravages of joint degradation, and surgery is sometimes used to replace joints that have been severely damaged. A relatively new therapy entails a series of injections of a lubricating fluid directly into the knee joint. These methods are of limited use, however, and can be very expensive—and, as with painkillers, they do not affect the disease itself.
One of the Holy Grails of conventional medicine is to find a drug that can stop the progression of OA. These are safe, effective, natural compounds that are used as nutritional supplements. Although glucosamine and chondroitin are helpful in relieving the symptoms of OA, their primary benefit lies in improving the structure of the affected joints, i. If cartilage becomes worn or degraded, however, as often occurs in aging joints especially the knees, which take relentless pounding throughout our lives , there can be hell to pay.
Bone rubs against bone, inflammation ensues, and the pain can be debilitating. What our joints need preferably long before this scenario has had a chance to occur is an abundant supply of proteoglycans in order to maintain healthy cartilage.
Whereas glucosamine sulfate is a single chemical compound, chondroitin sulfate is actually a mixture of closely related compounds, consisting mainly of two forms called chondroitin 4-sulfate and chondroitin 6-sulfate—a combination called chondroitin 4,6-sulfates for short.
Some researchers believe that the beneficial effects of chondroitin sulfate supplements may depend in part on the ratio of the 4-sulfate to the 6-sulfate in the mixture, with a preference for a ratio. Despite abundant evidence of the safety and efficacy of glucosamine and chondroitin, however, many physicians who may not be familiar with the literature on them are skeptical, because they tend to be skeptical of supplements in general.
The literature keeps on coming, however, and these arthritis-fighting agents are sure to become more widely accepted by mainstream medicine as time goes on. The latest study from the Belgian scientists actually, two 3-year studies, conducted as randomized, double-blind, placebo-controlled trials, and published in one paper shows again why glucosamine should be an integral part of every treatment plan for patients with OA.
This is the population most affected by OA. The results were most gratifying. After 3 years, the women who had been taking glucosamine sulfate showed no narrowing of the joint-space width in their knees—indicating no progression of the disease—whereas the women on placebo had a narrowing of 0.
Women in the glucosamine sulfate group reported improvements in pain and mobility, but not in stiffness. I know all too well how frustrating it can be when it comes to educating those who are not well versed in alternative medicine about the significant benefits that many types of supplements can have in combating debilitating illnesses, such as osteoarthritis.
Erosive osteoarthritis EOA of the hands causes significant inflammation and pain in its victims, and it can severely limit their ability to perform even the most basic tasks of everyday life. As with OA of the knees, conventional medicine can offer pain relief, but no real protection against progression of the disease. Studies have shown, however, that chondroitin may decrease the rate of progression of the disease in addition to providing symptomatic relief.
In a recent study, researchers in Italy gave patients with EOA of the hands 22 women and 2 men, average age 53 either mg of naproxen a commonly used NSAID or naproxen plus mg of chondroitin sulfate, daily; both groups took naproxen when necessary for pain relief.
All the patients in this study showed progressive worsening of their EOA, with increases in the number of joints affected, but the rate of worsening was slightly slower in those taking chondroitin sulfate.
On the other hand, the global assessment of disease activity, carried out by the patients and the physicians, showed no changes from baseline in the treated group, but a significant worsening in the untreated group. These products are not intended to diagnose, treat, cure, or prevent any disease. Postmenopausal Women Benefit from Glucosamine. Edward R. Rosick As the only practitioner of complementary and alternative medicine in a multicenter practice in central Pennsylvania an area not known, at least in terms of its medical community, for embracing change , it can be frustrating to try to educate my colleagues on the usefulness of supplements in maintaining optimal health.
Osteoarthritis—Disabler of Millions Osteoarthritis OA is one of the most common and debilitating diseases to afflict middle-aged and elderly people. Scientific Evidence for Glucosamine and Chondroitin Piles Up In the field of nutritional supplements, few substances have been as well documented for their intended purpose as glucosamine and chondroitin.
The authors stated, Results of the present study suggest that long-term oral administration of glucosamine sulfate for 3 years can delay the natural symptomatic and structural course of knee osteoarthritis in postmenopausal women. A Little Knowledge Is a Wonderful Thing I know all too well how frustrating it can be when it comes to educating those who are not well versed in alternative medicine about the significant benefits that many types of supplements can have in combating debilitating illnesses, such as osteoarthritis.
References McAlindon T. Glucosamine for osteoarthritis: dawn of a new era? The effect of glucosamine-chondroitin supplementation on glycosylated hemoglobin levels in patients with type 2 diabetes mellitus: a placebo-controlled, double-blinded, randomized clinical trial. Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial. Naturocetic glucosamine and chondroitin sulfate compounds as structure-modifying drugs in the treatment of osteoarthritis.
Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: a comprehensive meta-analysis. Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis. Glucosamine sulfate reduces osteoarthritis progression in postmenopausal women with knee osteoarthritis: evidence from two 3-year studies.
A two-year study of chondroitin sulfate in erosive osteoarthritis of the hands: behavior of erosions, osteophytes, pain, and hand dysfunction. Rosick is an attending physician and clinical assistant professor of medicine at Pennsylvania State University, where he specializes in preventive and alternative medicine. Sign up for our Newsletter.
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Glucosamine and Chondroitin for Osteoarthritis Pain
Glucosamine sulphate and glucosamine hydrochloride are nutritional supplements. Animal studies have found that glucosamine can both delay the breakdown of and repair damaged cartilage. The results for the use of glucosamine for osteoarthritis are mixed and the size of the effect is modest. Evidence from trials on glucosamine hydrochloride is scarce and not convincing.
Medically reviewed by Drugs. Last updated on Oct 30, Scientific Name s : 2-aminodeoxyglucose. Glucosamine is being investigated extensively for its action in osteoarthritis. However, there is a lack of consensus in clinical trials regarding its efficacy.
Glucosamine and Chondroitin for Osteoarthritis
Glucosamine is a dietary supplement that is often combined with another supplement, chondroitin , to treat osteoarthritis. Glucosamine is made from the shells of shellfish and chondroitin is derived from cow trachea. Evidence published in the New England Journal of Medicine has suggested that glucosamine alone or combined with chondroitin can help relieve osteoarthritis pain in a subgroup of people with moderate to severe knee osteoarthritis. Supplements advertised for improved joint health can be confusing and even downright misleading. Because supplements don't undergo the rigorous testing that pharmaceutical drugs do, the "recommended" dose is less supported by hard clinical evidence. And that can be a problem. If you take too little, you won't achieve a beneficial effect and you are essentially wasting your money.
The latest on glucosamine/chondroitin supplements
Glucosamine and chondroitin are structural components of cartilage, the tissue that cushions the joints. Both are produced naturally in the body. They are also available as dietary supplements. Researchers have studied the effects of these supplements, individually or in combination, on osteoarthritis, a common type of arthritis that destroys cartilage in the joints. More information.
Joint health concerns affect millions of Americans each year. Weight, genetics and occupational strains play a role, but joint health concerns are more prevalent in older adults because aging affects your joints. Glucosamine is one of the most popular joint-health supplements on the market. While your body produces its own natural supply, many people turn to dietary supplements to help maintain higher levels of glucosamine to support joints and help protect cartilage from the effects of aging.
To learn more about how this article was written, please see the Natural Medicines Comprehensive Database methodology. Glucosamine Sulfate. What is it?SEE VIDEO BY TOPIC: Glucosamine/Chondroitin Are They Right For You
Glucosamine plays a vital role in building cartilage, and many people take it as a supplement to treat arthritis and osteoarthritis. It occurs naturally in the fluid around the joints, in animal bones, bone marrow, shellfish, and fungi. Glucosamine, especially glucosamine sulfate, is extracted from the shells of shellfish to make dietary supplements. A synthetic form is made in laboratories, also. In this article, we explain what glucosamine is, why it is taken as a supplement, and whether there is scientific evidence to prove it is effective.
Glucosamine is a naturally occurring compound that is chemically classified as an amino sugar 1. It serves as a building block for a variety of functional molecules in your body but is primarily recognized for developing and maintaining cartilage within your joints 1. Glucosamine is also found in some animal and other non-human tissues, including shellfish shells, animal bones and fungi. Supplemental forms of glucosamine are often made from these natural sources 2. Glucosamine is frequently used to both treat and prevent joint disorders, such as osteoarthritis. It may be taken orally or applied topically in a cream or salve 2. One test-tube study demonstrated a significant anti-inflammatory impact when glucosamine was applied to cells involved in bone formation 3. However, these results were not statistically significant 5.
Many of us live with joint pain; osteoarthritis affects 1 in 10 people in the UK, and many also suffer injuries from sports or accidents. So we tested nine glucosamine supplement brands readily available in the UK, to see whether they contained the amount of glucosamine claimed on the bottle. Dr Cristina Legido-Quigley and her team at Kings College London's Institute of Pharmaceutical Science undertook that analysis, and their tests revealed some surprising discrepancies.
What Is Glucosamine?
Enter your email and we'll keep you on top of the latest nutrition research, supplement myths, and more. Our evidence-based analysis on glucosamine features unique references to scientific papers. Each member of our research team is required to have no conflicts of interest, including with supplement manufacturers, food companies, and industry funders.
Postmenopausal Women Benefit from Glucosamine
Glucosamine is a natural substance found in cartilage. In the US, it is sold as a dietary supplement and promoted to reduce osteoarthritis pain. It is generally safe and well-tolerated.
Glucosamine is a natural compound found in cartilage — the tough tissue that cushions joints. In supplement form, glucosamine is harvested from shells of shellfish or made in a lab. There are several forms of glucosamine, including glucosamine sulfate, glucosamine hydrochloride and N-acetyl glucosamine. These supplements are not considered interchangeable.
Glucosamine: Should I try it?
Patients should always consult a health professional before changing their diet or taking any over-the-counter drugs or nutritional supplements also known as dietary supplements or natural supplements. Only patients who have been diagnosed with osteoarthritis by a health professional and have had other possible causes for their back pain ruled out are candidates for glucosamine and chondroitin sulfate supplements. Patients should inform their physician of any other medications they are taking and of their medical history before taking any type of dietary supplement. See Osteoarthritis Complete Treatment Guide. In general, glucosamine and chondroitin sulfate nutritional supplements appear to be quite safe. The most common side effects occur that have been reported are gastrointestinal in nature, such as upset stomach, nausea, heartburn, and diarrhea. To date, no significant side effects have been reported, although long-term studies on the safety of glucosamine and chondroitin sulfate supplements still need to be completed.
How Much Glucosamine Chondroitin Should You Take?
Эту женщину, которая смотрела на него из другого мира. Она наблюдает за тем, как я умираю. - Дэвид… Голос показался ему знакомым. Наверное, эта женщина - ангел.